HPV vs Pap Test HPV vs Pap Test
Preventive Care
Women’s Health

HPV Test vs. Pap Test: Understanding the Difference

04 November 2025 · 5 mins read

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HPV tests detect high-risk virus types linked to cervical cancer, while Pap tests identify abnormal cervical cells. Both are key for early detection and care.

Cervical cancer screening plays a crucial role in early detection and prevention. However, many individuals may not be aware of the distinctions between the HPV test and the Pap test, both of which are important yet serve different purposes.

HPV Test: This test identifies high-risk strains of the human papillomavirus (HPV) that are known to cause cervical cancer. It detects the presence of the virus even before any changes to cervical cells have occurred.

Pap Test (Pap Smear): This screening examines cervical cells for abnormalities that may suggest precancerous or cancerous developments. It does not test for HPV directly but identifies changes typically caused by the virus.

Both tests are essential to cervical health and may be used together in co-testing. Screening recommendations depend on age, medical background, and personal risk factors. According to the National Institutes of Health (NIH), organised cervical screening programmes have lowered cervical cancer rates by 50% to 80% globally. Gleneagles Hospitals offer advanced cervical cancer screening supported by experienced healthcare professionals and modern diagnostic tools.

Causes of HPV and Cervical Cancer

Cervical cancer is strongly linked to persistent infection with high-risk HPV strains. Understanding the causes and risk factors contributes to effective prevention.

Transmission of HPV:

  • HPV is a sexually transmitted infection (STI), typically spread through skin-to-skin contact during sexual activity.
  • Engaging in unprotected sex or having multiple sexual partners increases the likelihood of contracting HPV.

Risk Factors for Cervical Cancer:

  • Persistent infection with high-risk HPV types
  • Weakened immune system (e.g., due to HIV)
  • Smoking, which damages cervical cells and weakens immune defences
  • Prolonged use of oral contraceptives
  • Early onset of sexual activity

The World Health Organization (WHO) has identified HPV types 16 and 18 as being responsible for approximately 70% of cervical cancer cases worldwide.

Benefits of HPV and Pap Tests

HPV Test:

  • Early Detection: Identifies high-risk HPV before cellular changes occur.
  • Extended Screening Intervals: For individuals aged 30 and older, a negative result may allow for longer intervals between tests.
  • Targeted Monitoring: Helps identify higher-risk individuals who may benefit from increased surveillance or early intervention.

Pap Test:

  • Detection of Cell Abnormalities: Identifies abnormal or precancerous cells at an early stage.
  • Proven Reliability: With decades of application, the Pap test has significantly contributed to reduced rates of cervical cancer.
  • Informed Follow-up: Results may lead to further diagnostic assessments, such as a colposcopy.

Routine cervical cancer screening, particularly through co-testing, has been shown to improve accuracy and outcomes, as noted by the American Cancer Society (ACS).

Effects on Fertility Health

Concerns about fertility are common among individuals undergoing cervical screening or treatment. It is important to clarify that the HPV and Pap tests are safe and non-invasive procedures involving the collection of cervical cell samples. These tests do not affect fertility.

Fertility concerns usually arise when further treatment is required following abnormal results. Procedures such as cryotherapy, laser therapy, or cone biopsy are used to remove or treat abnormal cervical cells. While these treatments are effective, certain procedures may slightly increase the risk of complications during future pregnancies, such as cervical incompetence or preterm birth.

Advancements in medical techniques have helped reduce these risks significantly. If there are concerns about reproductive health following screening or treatment, consulting a fertility specialist is advisable. At Gleneagles Hospitals, patients have access to experienced consultants who offer comprehensive guidance tailored to individual fertility goals.

Schedule an Appointment at Gleneagles Hospitals

Understanding the unique roles of the HPV and Pap tests, their advantages, and their implications for reproductive health allows individuals to make informed decisions about their well-being. Regular cervical cancer screening, combined with HPV vaccination and a healthy lifestyle, significantly lowers the risk of developing cervical cancer.

Gleneagles Hospitals provide personalised and comprehensive cervical health services, utilising up-to-date screening methods and offering consultations with qualified specialists. To book an appointment, visit our website or download the MyHealth360 mobile application from the Google Play Store or the Apple App Store. We are committed to supporting your health every step of the way.

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